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Quantitative Biology > Tissues and Organs

arXiv:2012.08252 (q-bio)
[Submitted on 15 Dec 2020]

Title:Mathematical model of brain tumour growth with drug resistance

Authors:José Trobia, Kun Tian, Antonio Marcos Batista, Celso Grebogi, Hai-Peng Ren, Moises Souza Santos, Paulo Ricardo Protachevicz, Fernando da Silva Borges, José Danilo Szezech Jr, Ricardo Luiz Viana, Iberê Luiz Caldas, Kelly Cristiane Iarosz
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Abstract:Brain tumours are masses of abnormal cells that can grow in an uncontrolled way in the brain. There are different types of malignant brain tumours. Gliomas are malignant brain tumours that grow from glial cells and are identified as astrocytoma, oligodendroglioma, and ependymoma. We study a mathematical model that describes glia-neuron interaction, glioma, and chemotherapeutic agent. In this work, we consider drug sensitive and resistant glioma cells. We show that continuous and pulsed chemotherapy can kill glioma cells with a minimal loss of neurons.
Subjects: Tissues and Organs (q-bio.TO); Biological Physics (physics.bio-ph)
Cite as: arXiv:2012.08252 [q-bio.TO]
  (or arXiv:2012.08252v1 [q-bio.TO] for this version)
  https://doi.org/10.48550/arXiv.2012.08252
Related DOI: https://doi.org/10.1016/j.cnsns.2021.106013

Submission history

From: Kelly Iarosz [view email]
[v1] Tue, 15 Dec 2020 12:40:04 UTC (708 KB)
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